It is a novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist. It is approved for diabetes and weight loss in obesity.

The total cost for the Low and Medium dose (up to 7.5 mg weekly) is $ 375 a month, including provider visit, medication and shipping costs. If you need more than 7.5 mg weekly dose the cost of the treatment is significantly more expensive – $600 a month.

The total cost is $600 a month, includes provider visit, medication and shipping costs.

We do not prescribe 15 mg weekly dose.

Let me summarize the results published in July 21, 2022 NEJM

5 mg weekly dose – mean weight loss 15%, a 200 lbs patient is expected to lose 30 lbs.

10 mg weekly dose – mean weight loss 19.5%

15 mg weekly dose – mean weight loss 20.9%

Based on these results, we recommend using 5 mg or 10 mg doses. However since the cost of 7.5 mg weekly is more reasonable compared to 10 mg dose this is the most economical option for my patients.

Most patients usually only need low and medium dose to achieve the desired weight loss ( up to 15% – 20%)

Based on the trials, patients lost up to 15% – 20% from the baseline.

We start you on low dose of 2.5 mg weekly for first 4 weeks. and increase dose after 4 weeks to 5 mg weekly.

During next few weeks you remain on 5 mg weekly dose if you continue to lose weight. However if the 15% weight loss is not achieved then we increase dose to 7.5 weekly after 16 weeks of treatment.

After you met with the prescriber, they will order the medication for you.

The medication is shipped directly to your home from the Compunding Pharmacy.

We recommend for you to store Tirzepatide in the refrigerator.

Tirzepatide in an injection form. You need to draw the prescribed amount of medication from the vial.
Use proper sterile technique. Clean the site with alcohol swab before injecting.
The needle provided to you is for subcutaneous injection. The needle goes below the skin level.
It is safe to inject on abdomen, upper part of the arm or thigh. Use different sites every week to inject.

GLP-1 Receptor Activation: Tirzepatide activates the GLP-1 receptors in the body. GLP-1 is a naturally occurring hormone that is released from the intestine in response to food intake. It plays a crucial role in regulating blood sugar levels.

Glucose Regulation: By activating GLP-1 receptors, semaglutide increases insulin secretion from the pancreas in a glucose-dependent manner. This means that insulin is released when blood sugar levels are elevated, helping to bring them down.

Insulin Sensitivity: Tirzepatide also improves insulin sensitivity in peripheral tissues like muscles and liver. This means that the body becomes more responsive to the action of insulin, allowing it to utilize glucose more effectively.

Slowing Gastric Emptying: Another effect of semaglutide is the slowing down of gastric emptying, which refers to the rate at which food leaves the stomach and enters the intestines. By delaying gastric emptying, Tirzepatide helps to control the rise in blood sugar after meals.

Reduced Appetite: Tirzepatide also acts on the brain’s appetite centers, leading to a decrease in appetite and a feeling of fullness. This can contribute to weight loss, and that’s why semaglutide is also being explored as an obesity treatment.

It is FDA approved medication but can have side effects.

Common side effects of Tirzepatide can include:

Gastrointestinal Symptoms: The most frequently reported side effects are gastrointestinal in nature, such as nausea, vomiting, diarrhea, and constipation. These symptoms are usually mild to moderate and tend to improve over time.

Hypoglycemia: Semaglutide, when used in combination with other blood sugar-lowering medications like sulfonylureas or insulin, can increase the risk of hypoglycemia (low blood sugar). It is important to closely monitor blood sugar levels and adjust the dosage of other medications as needed.

Injection Site Reactions: Some individuals may experience injection site reactions, such as redness, itching, or swelling at the injection site. Proper injection techniques can help minimize these reactions.

Gallbladder Disorders: There have been rare reports of gallbladder-related adverse events, including gallstones and inflammation of the gallbladder.

It’s worth noting that the safety and side effects of tirzepatide may vary among individuals, and some people may experience different or no side effects at all. It’s essential for you to call us, or email us if you experience any side effects. Incase of moderate to severe side effects please go to the nearby emergency room.

After initial treatment with Phentermine/Topamax for few months the patient is swithced over to Tirzepatide.
This approach helps patients to maximise weight loss by working different mechanism of actions of medications.